1. Staff

Kiran Mysore, Ph.D.

Professor

Current Research

problem
The Problem

World population is increasing at an alarming rate. World food production has to increase by 70 to 80 percent in the next 20 to 30 years to feed the world. One aspect that can contribute to increased food production is to reduce losses from both biotic and abiotic stresses. Diseases (a biotic stress) cause significant loss to food production. Disease resistance genes have been incorporated into crop plants through breeding, but they are only specific to certain races of pathogens.

approach
The Approach

A given plant is almost always resistant to pathogens due to broad-spectrum resistance called nonhost resistance. Disease is the only exception. The Molecular Plant Microbe laboratory is using several functional genomics (eg., virus-induced gene silencing) and genetic approaches (eg., mutant screening) in model plants to identify plant genes that contribute to nonhost resistance. Identification and characterization of these genes will be critical to engineer crops for durable and broad-spectrum disease resistance. Translational research is being carried out in forage and food crops to confer durable disease resistance.

Current Projects

  • Identifying and characterizing plant genes in nonhost disease resistance
  • Omics approach to understand the disease resistance and susceptibility to cotton root rot fungus (Phymatotrichopsis onmivora)
  • Optimizing or improving virus-induced gene silencing in crops such as sorghum and cassava
  • Identifying and characterizing plant genes involved in Agrobacterium-mediated plant transformation
  • Translational research to confer biotic and abiotic stress (drought) tolerance in crop plants.
  • Tnt1 insertion mutagenesis in Medicago truncatula and Brachypodium distachyon
Education
  • Doctor of Philosophy in Genetics, Purdue University, 1999
  • Master of Science in Horticulture, Clemson University, 1994
  • Bachelor of Science in Agriculture, University of Agricultural Sciences in Bangalore, India, 1991
Grants

Project Title: Epigenetic breeding in crops
Source: Bill and Melinda Gates Foundation
Term: 2013 to 2016

Project Title: GEPR: Genetic and cellular dissection of mutualistic plant-microbe
symbioses in Medicago truncatula
Source: National Science Foundation Plant Genome Program
Term: 2012 to 2016

Project Title: MRI: Acquisition of a UPLC/MS/SPE/NMR for plant metabolomics
Granting Agency: National Science Foundation
Source: National Science Foundation
Term: 2011 to 2015

Project Title: Characterization of Medicago truncatula genes involved in resistance/tolerance to Asian soybean rust
Source: BASF Plant Sciences
Term: 2011 to 2012

Project Title: Plant genes involved in nonhost disease resistance
Source: Oklahoma Center for the Advancement of Science and Technology
Term: 2009 to 2011

Project Title: EPSCoR Research Infrastructure Improvement Plan "Building Oklahoma's Leadership Role in Cellulosic Bioenergy" (Subtitle for Mysore Lab Project: Engineering switch grass to confer broad spectrum disease resistance
Source: National Science Foundation/Oklahoma EPSCoR
Term: 2008 to 2013

Project Title: Identification of Medicago truncatula genes involved in resistance/tolerance to Asian soybean rust fungus using a forward genetics approach
Source: BASF Plant Sciences
Term: 2008 to 2011

Project Title: MRI: Acquisition of a spinning disk confocal microscope for rapid imaging of plant cellular processes
Source: National Science Foundation
Term: 2007 to 2010

Project Title: Development of genetic resources in Medicago truncatula to dissect the regulatory networks governing legume nodule development and differentiation
Source: National Science Foundation Plant Genome Program
Term: 2007 to 2011

Project Title: A functional genomics approach to identify signaling components involved in defense responses induced by the ethylene induced xylanase elicitor
Source: U.S.-Israel Binational Agricultural Research and Development Fund
Term: 2006 to 2009

Project Title: Characterization of Medicago-Phymatotrichopsis omnivora interactions
Source: The State of Oklahoma (Oklahoma Legume Consortium)
Term: 2005 to 2009

Project Title: A novel approach to identify plant genes involved in Agrobacterium-mediated transformation
Source: National Science Foundation
Term: 2005 to 2009

Honors
  • Leadership award, Ardmore Leadership Program, 2015
  • Noble Research Institute Leadership Program participant, 2014-2015
  • H. Ismail Doctoral Research Travel Award, Purdue University, 1997
  • Keystone Symposium travel award, 1997
  • Special Initiative University Pre-doctoral Fellowship, Purdue University, 1994-1995
  • Wade Stackhouse Fellowship, Clemson University, 1993-1994
  • University Merit Scholarship, University of Agricultural Sciences, India, 1991-1992
Patents
  • Ryu, et al., Root agroinoculation method for virus-induced gene silencing. U.S. Patent No. 7,476,780 (issued Jan 13, 2009).
  • Anand, et al., Method for Agrobacterium-mediated transformation of plants. U.S. Patent No. 8,053,638 (issued Nov 8, 2011).
  • Uppalapati, et al., Disease resistant plants. U.S. Patent No. 8,138,392 (issued Mar 20, 2012).
  • Vaghchhipawala, et al., Methods and compositions for increasing plant transformation efficiency. U.S. Patent No. 8,669,417 (issued Mar 11, 2014).
  • Tadege, et al., Methods and compositions for altering plant biomass. U.S. Patent No. 9,074,216 (issued Jul 7, 2015).
  • Li, et al., Metabolic engineering of plant disease resistance. U.S. Patent No. 9,238,821 (Jan 19, 2016).