Sumner Group Publications

Tzin, V., Malitsky, S., Moyal Ben Zvi, M., Bedair, M., Sumner, L. W., Aharoni, A., & Galili, G. (2012). Expression of a bacterial feedback-insensitive 3-deoxy-D-arabinoheptulosonate 7-phosphate synthase of the shikimate pathway in Arabidopsis elucidates potential metabolic bottlenecks between primary and secondary metabolism. New Phytologist, February, doi: 10.1111/j.1469-8137.2012.04052.x.

Ruiz-May, E., De-la-Pena, C., Galaz-Ávalos, R. M, Lei, Z., Watson, B. S., Sumner, L. W., & Loyola-Vargas, V. M. (2011). Methyl jasmonate induces ATP biosynthesis deficiency and accumulation of proteins related to secondary metabolism in Catharanthus roseus (L.) G. hairy roots. Plant Cell & Physiology, , doi:10.1093/pcp/pcr086.

Tadege, M., Lin, H., Bedair, M., Berbel, A., Wen, J. Q., Rojas, C. M. , Niu, L., Tang, Y., Sumner, L. W., Ratet, P., McHale, N. A. , Madueno, F, & Mysore, K. S. (2011). STENOFOLIA regulates blade outgrowth and leaf vascular patterning in Medicago truncatula and Nicotiana sylvestris. Plant Cell, 23 (6), 2125-2142 doi:10.1105/tpc.111.085340.

Lei, Z., Huhman, D. V., & Sumner, L. W. (2011). Mass spectrometry strategies in metabolomics. Journal of Biological Chemistry, 286 (29), 25435-42 doi:10.1074/jbc.R111.238691.

Lei, Z., Dai, X., Watson, T., Zhao, P. X., & Sumner, L. W. (2011). A legume specific protein database (LegProt) improves the number of identified peptides, confidence scores and overall protein identification success rates for legume proteomics. Phytochemistry, , doi:10.1016/j.phytochem.2011.01.026 .

Zhao, J., Huhman, D. V., Shadle, G., He, X-Z., Sumner, L. W., Tang, Y., & Dixon, R. A. (2011). MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula. Plant Cell, 23, doi:10.1105/tpc.110.080804.

Srivastava, A. C., Ramos-Parra, P. A. , Bedair, M., Robledo-Hernandez, A. L. , Tang, Y., Sumner, L. W., Diaz Garza, R. I., & Blancaflor, E. B. (2011). The folylpolyglutamate synthetase plastidial isoform is required for postembryonic root development in Arabidopsis. Plant Physiology, , doi:10.1104/pp.110.168278.

Pribat, A., Noiriel, A., Morse, A. M. , Davis, J. M. , Fouquet, R. F. , Loizeau, K., Ravanel, S., Haas, R. , Reski, R. , Bedair, M., Sumner, L. W., & Hanson, A. D. (2010). Non-flowering plants possess a unique folate-dependent phenylalanine hydroxylase that is localized in chloroplasts. Plant Cell, 22, 3410-3422 DOI:10.1105/tpc.110.078824.

Lei, Z., Chen, F., Watson, B. S., Nagaraj, S., Elmer, A. M., Dixon, R. A., & Sumner, L. W. (2010). Comparative proteomics of yeast-elicited Medicago truncatula cell suspensions reveal induction of isoflavonoid biosynthesis and cell wall modifications. Journal of Proteome Research, , DOI: 10.1021/pr100439k.

Sumner, L. W. (2010). Recent advances in plant metabolomics and greener pastures (abstract). Faculty of 1000 Biology , 2, 7 DOI:10.3410/B2-7.

Sumner, L. W. (2010). Legume metabolomics (special issue dedicated to Model Legumes). Grain Legumes Magazine , 53, 17.

Jiang, Q., Zhang, J - Y., Guo, X., Bedair, M., Sumner, L. W., Bouton, J. H., & Wang, Z - Y. (2010). Improvement of drought tolerance in white clover (Trifolium repens) by transgenis expression of a transaction factor gene WXP1. Functional Plant Biology, 37, 157-165 DOI:10.1071/FP09177.

Bais, P., Moon, S. M., He, K., Leitao, R., Walk, T., Sucaet, Y., Barken, L., Wohlgemuth, G., Roth, M. R., Wurtele, E. S., Dixon, P., Fiehn, O., Lange, B. M. , Shulaev, V., Sumner, L. W., Welti, R., Nikolau, B. J., Rhee, S. Y. , & Dickerson, J. (2010). PlantMetabolomics.org: A web portal for plant metabolomics experiments. Plant Physiology, 152, 1807-1816 DOI:10.1104/pp.109.151027 .

De-la-Pena, C., Badri, D. V., Lei, Z., Watson, B., Brandao, M., Silva-Filho, M.C., Sumner, L. W., & Vivanco, J. M. (2010). Root secretion of defense-related proteins is development-dependent and correlated with flowering time. Journal of Biological Chemistry, , DOI:10.1074/jbc.M110.119040.

Broz, A. K., Broeckling, C. D., De-la-Pena, C., Lewis, M. R., Greene, E., Callaway, R. M., Sumner, L. W., & Vivanco, J. M. (2010). Plant neighbor indentity influences plant biochemistry and physiology related to defence. Plant Biology, 10, 115 DOI:1471-2229/10/115.

Dobritsa, A. A., Lei, Z., Nishikawa, S - I., Urbanczyk-Wochniak, E., Huhman, D. V., Preuss, D., & Sumner, L. W. (2010). LAP5 and LAP6 encode anther-specific proteins with similarity to chalcone synthase essential for pollen exine development in Arabidopsis thaliana . Plant Physiology, May 4, DOI:10.1104/pp.110.157446 .

Brechenmacher, L., Lei, Z., Libault, M., Findley, S., Sugawara, M., Sadowsky, M. J. , Sumner, L. W., & Stacey, G. (2010). Soybean metabolites regulated in root hairs in response to the symbiotic bacterium Bradyrhizobium japonicum . Plant Physiology, 153 (4), 1808-1822 DOI:10.1104/pp.110.157800 .

Naoumkina, M., Modolo, L. V. , Huhman, D. V., Urbanczyk-Wochniak, E., Tang, Y., Sumner, L. W., & Dixon, R. A. (2010). Genomic and coexpression analyses predict multiple genes involved in triterpene saponin biosynthesis in Medicago truncatula. Plant Cell, 22, 850-866 DOI:10.1105/tpc.109.073270 .

Dai, X., Wang, G., Yang, D - S., Tang, Y., Broun, P., Marks, M. D., Sumner, L. W., Dixon, R. A., & Zhao, P. X. (2010). TrichOME: A comparative omics database for plant trichomes. Plant Physiology, 152, 44-54 DOI: 10.1104/pp.109.145813.

Dobritsa, A. A., Nishikawa, S - I., Preuss, D., Urbanczyk-Wochniak, E., Sumner, L. W., Hammond, A., Carlson, A. L., & Swanson, R. J. (2009). LAP3, a novel plant protein required for pollen development, is essential for proper exine formation. Sexual Plant Reproduction, 22 (3), 167-177 doi: 10.1007/s00497-009-0101-8.

Pang, Y., Wenger, J., Saathoff, K., Peel, G. J., Wen, J. Q., Huhman, D. V., Allen, S. N., Tang, Y., Cheng, X., Tadege, M., Ratet, P., Mysore, K. S., Sumner, L. W., Marks, M. D., & Dixon, R. A. (2009). A WD40 repeat protein from Medicago truncatula is necessary for tissue-specific anthocyanin and proanthocyanidin biosynthesis but not for trichome development. Plant Physiology, 151 (3), 1114-1129 DOI:10.1104/pp.109.144022.

Farag, M. A., Deavours, B., de Fatima, A., Naoumkina, M., Dixon, R. A., & Sumner, L. W. (2009). Integrated metabolite and transcript profiling identify a biosynthetic mechanism for Hispidol in Medicago truncatula cell cultures. Plant Physiology, 151 (3), 1096-1113 DOI:10.1104/pp.109.141481.

Sawasdipuksa, N., Sumner, L. W., Lei, Z., & Sangvanich, P. (2009). Proteome analysis of Pithecellobium dulce seeds using two-dimensional gel electrophoresis and tandem mass spectrometry . Journal of the Science of Food and Agriculture, 89 (8), 1284-1291.

Tian, L., Peel, G. J., Lei, Z., Aziz, N., Dai, X., He, J., Watson, B. S., Zhao, P. X., Sumner, L. W., & Dixon, R. A. (2009). Transcript and proteomic analysis of developing white lupin (Lupinus albus L.) roots. BMC Plant Biology, 9 (1), DOI:10.1186/1471-2229-9-1.

De-la-Pena, C., Lei, Z., Watson, B. S., Sumner, L. W., & Vivanco, J. M. (2008). Root-microbe communication through protein secretion. Journal of Biological Chemistry, 283 (37), 25247-25255 DOI:10.1074/jbc.M801967200.

Xu, P., Chen, F., Mannas, J. P. , Feldman, T., Sumner, L. W., & Roossinck, M. J. (2008). Virus infection improves drought tolerance. New Phytologist, 180 (4), 911-921 DOI: 10.1111/j.1469-8137.2008.02627.x.

Bedair, M., & Sumner, L. W. (2008). Current and emerging mass-spectrometry technologies for metabolomics. Trends in Analytical Chemistry, 27 (3), 238-250 DOI:10.1016/j.trac.2008.01.006.

Kaimoyo, E., Farag, M. A., Sumner, L. W., Wasmann, C., Cuello, J. L., & VanEtten, H. D. (2008). Sub-lethal Levels of electric current elicit the biosynthesis of plant secondary metabolites. Biotechnology Progress, 24 (2), 377-384 DOI:10.1021/bp0703329.

Badri, D. V., Loyola-Vargas, V. M., Broeckling, C. D., De-la-Pena, C., Jasinski, M., Santelia, D., Martinoia, E., Sumner, L. W., Banta, L. M., Stermitz, F., & Vivanco, J. (2008). Altered profile of secondary metabolites in the root exudates of Arabidopsis ATP-binding cassette transporter mutants. Plant Physiology, 146 (2), 762-771 DOI:10.1104/pp.107.109587.

Farag, M. A., Huhman, D. V., Dixon, R. A., & Sumner, L. W. (2008). Metabolomics reveals novel pathways and differential mechanistic and elicitor-specific responses in phenylpropanoid and isoflavonoid biosynthesis in Medicago truncatula cell cultures. Plant Physiology, 146 (2), 387-402 DOI:10.1104/pp.107.108431 .

Fiehn, O., Sumner, L. W., Rhee, S. Y. , Ward, J., Lange, B. M. , Lane, G., Roessner, U., Last, R., & Nikolau, B. J. (2007). Minimum reporting standards for plant biology context information in metabolomic studies. Metabolomics, 3 (3), 195-201.

Whaley, W. L., Rummel, J. D., Zemenu, E., Li, W., Yang, P., Rodgers, B., Bailey, J., Moody, J., Huhman, D. V., Maier, C., Sumner, L. W., & Starnes, S. D. (2007). Isolation and characterization of osajin and pomiferin: Discovery laboratory exercises for organic chemistry,. Chemical Educator, 12 (3), 179-184 DOI 10.1333/s00897072030a.

Naoumkina, M., Farag, M. A., Sumner, L. W., Tang, Y., Liu, C.-J., & Dixon, R. A. (2007). Different mechanisms for phytoalexin induction by pathogen and wound signals in Medicago truncatula. PNAS (Proceedings of the National Academy of Sciences), 104 (46), 17909-17915.

Zhang, J - Y., Broeckling, C. D., Sumner, L. W., & Wang, Z - Y. (2007). Heterologous expression of two Medicago truncatula putative ERF transcription factor genes, WXP1 and WXP2, in Arabidopsis led to increased leaf wax accumulation and improved drought tolerance, but differential response in freezing tolerance. Plant Molecular Biology, 64 (3), 265-278.

Urbanczyk-Wochniak, E., & Sumner, L. W. (2007). MedicCyc: A biochemical pathway database for Medicago truncatula. Bioinformatics, 23 (11), 1418-1423.

Sansone, S. A., Fan, T., Goodacre, R., Griffin, J. L., Hardy, N., Kaddurah-Daouk, R., Kristal, B., Lindon, J., Mendes, P. J., Morrison, N., Nikolau, B. J., Robertson, D., Sumner, L. W., Taylor, C., van der Werf, M., & Fiehn, O. (2007). The metabolomics standards initiative. Nature Biotechnology, 25 (8), 846-848.

Farag, M. A., Huhman, D. V., Lei, Z., & Sumner, L. W. (2007). Metabolic profiling and systematic identification of flavonoids and isoflavonoids in roots and cell suspension cultures of Medicago truncatula using HPLC-UV-ESI-MS and GC-MS. Phytochemistry, 68 (3), 342-354 doi:10.1016/j.phytochem.2006.10.023.

Williams, B. J. , Cameron, C. J., Workman, R., Broeckling, C. D., Sumner, L. W., & Smith, J. T. (2006). Amino acid profiling in plant cell cultures: An inter-laboratory comparison of CE-MS and GC-MS. Electrophorsis, 28, 1371-1379.

Sumner, L. W., Shahandeh, H, Bouton, J. H., & Hammel, J. (2006). Amelioration of an acid soil profile through deep liming and surface application of gypsum. Soil Science, 50 (55), 1254-1258.

Zhou, L., Hopkins, A. A., Huhman, D. V., & Sumner, L. W. (2006). Efficient and sensitive method for quantitative analysis of alkaloids in hardinggrass (Phalaris aquatica L.). Journal of Agricultural and Food Chemistry, 54 (25), 9287-9291.

Deavours, B., Liu, C.-J., Naoumkina, M., Tang, Y., Farag, M. A., Sumner, L. W., Noel, J. P., & Dixon, R. A. (2006). Functional analysis of members of the isoflavone and isoflavanone O-methyltransferase enzyme families from the model legume Medicago truncatula. Plant Molecular Biology, 62 (4-5), 715-733 doi: 10.1007/s11103-006-9050-x .

Fiehn, O., Kristal, B., van Ommen, B., Sumner, L. W., Sansone, S. A., Taylor, C., & Kaddurah-Daouk, R. (2006). Establishing reporting standards for metabolomic and metabonomic studies: A call for participation. Omics, 10 (2), 158-163.

Farag, M. A., Ryu, C-M., Sumner, L. W., & Pare, P. W. (2006). GC-MS SPME profiling of rhizobacterial volatiles reveals prospective inducers of growth promotion and induced systemic resistance in plants. Phytochemistry, 67 (20), 2262-2268.

Broeckling, C. D., Reddy, I. R., Duran, A. L., Zhao, P. X., & Sumner, L. W. (2006). MET-IDEA: Data extraction tool for mass spectrometry-based metabolomics. Analytical Chemistry, 78 (13), 4334-4341 doi: 10.1021/ac0521596.

Zhang, J - Y., Broeckling, C. D., Blancaflor, E. B. , Sledge, M. K., Sumner, L. W., & Wang, Z - Y. (2005). Overexpression of WXP1, a putative Medicago truncatula AP2 domain-containing transcription factor gene, increases cuticular wax accumulation and enhances drought tolerance in transgenic alfalfa (Medicago truncatula). Plant Journal, 42 (5), 689-707 doi:10.1111/j.1365-313X.2005.02405.x.

Tarpley, L., Duran, A. L., Kebrom, T. H., & Sumner, L. W. (2005). Biomarker metabolites capturing the metabolite variance present in a rice plant developmental period. BMC Plant Biology, 5 (8), doi:10.1186/1471-2229-5-8.

Lei, Z., Elmer, A. M., Watson, B. S., Dixon, R. A., Mendes, P. J., & Sumner, L. W. (2005). A two-dimensional electrophoresis proteomic reference map and systematic identification of 1367 proteins from a cell suspension culture of the model legume Medicago truncatula. Molecular and Cellular Proteomics, 4 (11), 1812-1825 doi:10.1074/mcp.D500005-MCP200.

Frydman, A., Weisshaus, O., Huhman, D. V., Sumner, L. W., Bar-Peled, M., Lewinsohn, E., & Flurh, R. (2005). Metabolic engineering of plant cells for biotransformation of hesperedin into neohesperidin, a substrate for production of the low-calorie sweetener and flavor enhancer NHDC. Journal of Agricultural and Food Chemistry, 53 (25), 9708-9712.

Broeckling, C. D., Huhman, D. V., Farag, M. A., Smith, J. T., May, G. D., Mendes, P. J., Dixon, R. A., & Sumner, L. W. (2005). Metabolic profiling of Medicago truncatula cell cultures reveals the effects of biotic and abiotic elicitors on metabolism. Journal of Experimental Botany, 56 (410), 323-336 doi:10.1093/jxb/eri058.

Huhman, D. V., Berhow, M. A., & Sumner, L. W. (2005). Quantification of saponins in aerial and subterranean tissues of Medicago truncatuala. Journal of Agricultural and Food Chemistry, 53 (6), 1914-1920.

Achnine, L., Huhman, D. V., Farag, M. A., Sumner, L. W., Blount, J. W., & Dixon, R. A. (2005). Genomics-based selection and functional characterization of triterpene glycosyltransferases from the model legume Medicago truncatula. Plant Journal, 41 (6), 875-887 doi:10.1111/j.1365-313X.2005.02344..

Suzuki, H., Reddy, M .S. , Naoumkina, M., Aziz, N., May, G. D., Huhman, D. V., Sumner, L. W., Blount, J. W., Mendes, P. J., & Dixon, R. A. (2005). Methyl jasmonate and yeast elicitor induce differential transcriptional and metabolic re-programming in cell suspension cultures of the model legume Medicago truncatula. Planta, 220 (5), 696-707 doi:10.1007/s00425-004-1387-2 /.

Hensley, K., Mou, S., Pye, Q., Dixon, R. A., Sumner, L. W., & Floyd, R. D. (2004). Chemical versus pharmacological actions of nutraceutical phytochemicals: antioxidant and anti inflammatory modalities. Journal of Nutraceutical Research, 2 (1), 13-26.

Jenkins, H., Hardy, N., Beckmann, M., Draper, J., Smith, J. T., Taylor, J. M., Fiehn, O., Goodacre, R., Bino, R. J., Hall, R. D., Kopka, J., Lange, B. M. , Lui, J. R., Mendes, P. J., Nikolau, B. J., Oliver, S. G., Paton, N., Roessner-Tunali, U., Saito, K., Smedsgaard, J., Sumner, L. W., Wurtele, E. S., & Kell, D. B. (2004). A proposed framework for the description of plant metabolomics experiments and their results. Nature Biotechnology, 22 (12), 1601-1606.

Frydman, A., Weisshaus, O., Bar-Peled, M., Huhman, D. V., Sumner, L. W., Marin, F. R., Lewinsohn, E., Flurh, R., Gressel, J., & Eyal, Y. (2004). Citrus fruit bitter flavors: isolation and the functional characterization of the gene Cm1,2RhaT encoding a 1,2 rhamnosyltransferase, a key enzyme of the biosynthesis of the bitter flavonoids of citru. Plant Journal, 40 (1), 88-100.

Bino, R. J., Hall, R. D., Fiehn, O., Kopka, J., Saito, K., Draper, J., Nikolau, B. J., Mendes, P. J., Roessner-Tunali, U., Beale, M. H., Threthewey, R. N. , Lange, B. M. , Wurtele, E. S., & Sumner, L. W. (2004). Potential of metabolomics as a functional genomics tool. Trends in Plant Science, 9 (9), 418-425 doi:10.1016/j.tplants.2004.07.004.

Anand, A., Lei, Z., Sumner, L. W., Mysore, K. S., Arakane, Y., Bockus, W. W., & Muthukrishnan, S. (2004). Apoplastic extracts from a transgenic wheat line exhibiting lesion-mimic phenotype have multiple pathogenesis-related proteins that are antifungal. Molecular Plant-Microbe Interactions, 17 (12), 1306-1317 doi:10.1094/MPMI.2004.17.12.1306.

Watson, B. S., Lei, Z., Dixon, R. A., & Sumner, L. W. (2004). Proteomics of Medicago sativa cell walls. Phytochemistry, 65 (12), 1709-1720 doi:10.1016/j.phytochem.2004.04.026.

Noel, J. P., Dixon, R. A., Pichersky, E., Zubieta, C., & Sumner, L. W. (2003). Structural, functional, and evolutionary basis for methylation of plant small molecules. Recent Advances in Phytochemistry, 37, 37-58 doi:10.1016/S0079-9920(03)80017-5.

Sumner, L. W., Mendes, P. J., & Dixon, R. A. (2003). Plant Metabolomics:Large-scale phytochemistry in the functional genomics era. Phytochemistry, 62 (6), 817-836 doi:10.1016/S0031-9422(02)00708-2.

Watson, B. S., Asirvatham, V. S. , Wang, L - J., & Sumner, L. W. (2003). Mapping the proteome of Barrel Medic (Medicago truncatula). Plant Physiology, 131 (3), 1004-1123.

Dixon, R. A., & Sumner, L. W. (2003). Legume natural products: Understanding and manipulating complex pathways for human and animal health. Plant Physiology, 131 (March), 878-885.

Duran, A. L., Yang, J., Wang, L - J., & Sumner, L. W. (2003). Metabolomics spectral formatting, alignment and conversion tools. (MSFACTs). Bioinformatics, 19 (17), 2283-2293.

Liu, C.-J., Huhman, D. V., Sumner, L. W., & Dixon, R. A. (2003). Regiospecific hydroxylation of isoflavones by cythchrome P450 81E enzymes from Medicago truncatula. Plant Journal, 36 (4), 471-484.

Chen, F., Duran, A. L., Blount, J. W., Sumner, L. W., & Dixon, R. A. (2003). Profiling phenolic metabolites in transgenic alfalfa modified in lignin biosynthesis. Phytochemistry, 64 (5), 1013-1021 doi:10.1016/S0031-9422(03)00463-1.

Hall, R. D., Beale, M. H., Fiehn, O., Hardy, N., Sumner, L. W., & Bino, R. J. (2002). Plant metabolomics; The missing link in functional genomics strategies. Plant Cell, 14, 1437-1440.

Sumner, L. W., Wolf-Sumner, B., White, S., & Asirvatham, V. S. (2002). Silver stain removal using H2o2 for enhancing peptide mass mapping by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry, 16 (3), 160-168.

Huhman, D. V., & Sumner, L. W. (2002). Metabolic profiling of saponins in Medicago sativa and Medicago truncatula using Hplc coupled to an electrospray ion-trap mass. Phytochemistry, 59, 347-360.

Blount, J. W., Masoud, S. A., Sumner, L. W., Huhman, D. V., & Dixon, R. A. (2002). Over-expression of cinnamate 4-hydroxylase leads to increased accumulation of acetosyringone in elicited tobacco cell-suspension cultures. Planta, 214 (6), 902-910.

Asirvatham, V. S. , Watson, B. S., & Sumner, L. W. (2002). Analytical and biological variances associated with proteomic studies of Medicago truncatula by two-dimensional polyacrylamide gel electrophoresis. Proteomics, 2 (8), 960-968.

Sumner, L. W. (1998). Definition of the redox states of cobalt-precorrinoids: Investigation of the substrate and redox specificity of CbiL from Salmonella typhimurium. Biochemistry, 37, 14917-14927 doi:10.1021/bi981366f .

Sumner, L. W., Paiva, N. L., Dixon, R. A., & Geno, P. W. (1996). High-performance liquid chromatography/continuous-flow liquid secondary ion mass spectrometry of flavonoid glucosides in leguminous plant extracts. Journal of Mass Spectrometry, 31 (5), 472-485.

Orr, J., Sumner, L. W., Edwards, R., & Dixon, R. A. (1993). Determinations of cinnamic acid and 4-coumaric acid in alfalfa (Medicago sativa L.) cell suspension cultures using gas chromatography. Phytochemical Analysis, 4, 124.

Freitas, M. A., Geno, P. W., Sumner, L. W., Cooks, M. E., Hudiburg, S. A., Ownby, C. L., Kaiser, A. D., & Odell, G. V. (1992). Citrate,a major component in snake venom. Toxicon, 30, 461.